Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome

Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depletion of all DNMTs in a pluripotent human tumor cell line, followed...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Tiedemann, Rochelle L., Putiri, Emily L., Lee, Jeong-Heon, Hlady, Ryan A., Kashiwagi, Katsunobu, Ordog, Tamas, Zhang, Zhiguo, Liu, Chen, Choi, Jeong-Hyeon, Robertson, Keith D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254561/
https://ncbi.nlm.nih.gov/pubmed/25453758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.013
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