Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma

Clear cell renal cell carcinomas (ccRCCs) harbor frequent mutations in epigenetic modifiers including SETD2, the H3K36me3 writer. We profiled DNA methylation (5mC) across the genome in cell line-based models of SETD2 inactivation and SETD2 mutant primary tumors because 5mC has been linked to H3K36me...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tiedemann, Rochelle L., Hlady, Ryan A., Hanavan, Paul D., Lake, Douglas F., Tibes, Raoul, Lee, Jeong-Heon, Choi, Jeong-Hyeon, Ho, Thai H., Robertson, Keith D.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811507/
https://ncbi.nlm.nih.gov/pubmed/26646321
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