Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome

Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depletion of all DNMTs in a pluripotent human tumor cell line, followed...

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Vydáno v:Cell Rep
Hlavní autoři: Tiedemann, Rochelle L., Putiri, Emily L., Lee, Jeong-Heon, Hlady, Ryan A., Kashiwagi, Katsunobu, Ordog, Tamas, Zhang, Zhiguo, Liu, Chen, Choi, Jeong-Hyeon, Robertson, Keith D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254561/
https://ncbi.nlm.nih.gov/pubmed/25453758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.013
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