Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA

Drugs that target DNA topoisomerase II isoforms and alkylate DNA represent two mechanistically distinct and clinically important classes of anticancer drugs. Guided by molecular modeling and docking a series of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds were designed, synthesized...

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Bibliographic Details
Published in:Bioorg Med Chem
Main Authors: Yadav, Arun A., Wu, Xing, Patel, Daywin, Yalowich, Jack C., Hasinoff, Brian B.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254203/
https://ncbi.nlm.nih.gov/pubmed/25282653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.014
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