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Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs

Drugs that target DNA topoisomerase II, such as the epipodophyllotoxin etoposide, are a clinically important class of anticancer agents. A recently published X-ray structure of a ternary complex of etoposide, cleaved DNA and topoisomerase IIβ showed that the two intercalated etoposide molecules in t...

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Dades bibliogràfiques
Publicat a:Bioorg Med Chem
Autors principals: Yadav, Arun A., Chee, Gaik-Lean, Wu, Xing, Patel, Daywin, Yalowich, Jack C., Hasinoff, Brian B.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461482/
https://ncbi.nlm.nih.gov/pubmed/25922181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.04.022
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