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Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs
Drugs that target DNA topoisomerase II, such as the epipodophyllotoxin etoposide, are a clinically important class of anticancer agents. A recently published X-ray structure of a ternary complex of etoposide, cleaved DNA and topoisomerase IIβ showed that the two intercalated etoposide molecules in t...
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| Publicat a: | Bioorg Med Chem |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461482/ https://ncbi.nlm.nih.gov/pubmed/25922181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.04.022 |
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