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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA

Drugs that target DNA topoisomerase II isoforms and alkylate DNA represent two mechanistically distinct and clinically important classes of anticancer drugs. Guided by molecular modeling and docking a series of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds were designed, synthesized...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Yadav, Arun A., Wu, Xing, Patel, Daywin, Yalowich, Jack C., Hasinoff, Brian B.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254203/
https://ncbi.nlm.nih.gov/pubmed/25282653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.014
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