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The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II
Dovitinib (TKI258/CHIR258) is a multi-kinase inhibitor in phase III development for the treatment of several cancers. Dovitinib is a benzimidazole-quinolinone compound that structurally resembles the bisbenzimidazole minor groove binding dye Hoechst 33258. Dovitinib bound to DNA as shown by its abil...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501595/ https://ncbi.nlm.nih.gov/pubmed/23041231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.09.023 |
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