Multi-factor data normalization enables the detection of copy number aberrations in amplicon sequencing data

Motivation: Because of its low cost, amplicon sequencing, also known as ultra-deep targeted sequencing, is now becoming widely used in oncology for detection of actionable mutations, i.e. mutations influencing cell sensitivity to targeted therapies. Amplicon sequencing is based on the polymerase cha...

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Bibliografiska uppgifter
I publikationen:Bioinformatics
Huvudupphovsmän: Boeva, Valentina, Popova, Tatiana, Lienard, Maxime, Toffoli, Sebastien, Kamal, Maud, Le Tourneau, Christophe, Gentien, David, Servant, Nicolas, Gestraud, Pierre, Rio Frio, Thomas, Hupé, Philippe, Barillot, Emmanuel, Laes, Jean-François
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
Ämnen:
Hitseq Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253825/
https://ncbi.nlm.nih.gov/pubmed/25016581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu436
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