Combinations of targeted therapies in human cancers

Por Decaudin, Didier, Le Tourneau, Christophe
Publicado no Aging (Albany NY) (2016)

Sunitinib: a novel tyrosine kinase inhibitor. A brief review of its therapeutic potential in the treatment of renal carcinoma and gastrointestinal stromal tumors (GIST)

Por Le Tourneau, Christophe, Raymond, Eric, Faivre, Sandrine
Publicado em 2007

Dose Escalation Methods in Phase I Cancer Clinical Trials

Por Le Tourneau, Christophe, Lee, J. Jack, Siu, Lillian L.
Publicado em 2009

Efficiency of New Dose Escalation Designs in Dose-Finding Phase I Trials of Molecularly Targeted Agents

Por Le Tourneau, Christophe, Gan, Hui K., Razak, Albiruni R. A., Paoletti, Xavier
Publicado em 2012

Phase II, randomized, open-label study of durvalumab (MEDI4736) or tremelimumab monotherapy, or durvalumab + tremelimumab, in patients with recurrent or metastatic (R/M) squamous c...

Por Gilbert, Jill, Le Tourneau, Christophe, Mehanna, Hisham, Fayette, Jerome, Goswami, Trishna, Emeribe, Ugochi, Jarkowski, Anthony, Melillo, Giovanni, Siu, Lilian L
Publicado no J Immunother Cancer (2015)

Prognostic factors of successful on-purpose tumor biopsies in metastatic cancer patients included in the SHIVA prospective clinical trial

Por Desportes, Emilie, Wagner, Mathilde, Kamal, Maud, Salomon, Anne Vincent, Deniziaut, Gabrielle, Pierron, Gaëlle, Rouleau, Etienne, Jouffroy, Thomas, Le Tourneau, Christophe, Paoletti, Xavier, Servois, Vincent
Publicado no Oncotarget (2016)

Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials

Por Hansen, Aaron R., Cook, Natalie, Ricci, M. Stacey, Razak, Albiruni, Le Tourneau, Christophe, McKeever, Kathleen, Roskos, Lorin, Dixit, Rakesh, Siu, Lillian L., Hinrichs, Mary Jane
Publicado no Oncologist (2015)

Multi-factor data normalization enables the detection of copy number aberrations in amplicon sequencing data

Por Boeva, Valentina, Popova, Tatiana, Lienard, Maxime, Toffoli, Sebastien, Kamal, Maud, Le Tourneau, Christophe, Gentien, David, Servant, Nicolas, Gestraud, Pierre, Rio Frio, Thomas, Hupé, Philippe, Barillot, Emmanuel, Laes, Jean-François
Publicado no Bioinformatics (2014)

A Phase I, Dose-Escalation Trial of Pazopanib in Combination with Cisplatin in Patients with Advanced Solid Tumors: A UNICANCER Study

Por Diéras, Véronique, Bachelot, Thomas, Campone, Mario, Isambert, Nicolas, Joly, Florence, Le Tourneau, Christophe, Cassier, Philippe, Bompas, Emmanuelle, Fumoleau, Pierre, Noal, Sabine, Orsini, Christine, Jimenez, Marta, Imbs, Diane Charlotte, Chatelut, Etienne
Publicado no Oncol Ther (2016)

Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials

Por Le Tourneau, Christophe, Kamal, Maud, Tsimberidou, Apostolia-Maria, Bedard, Philippe, Pierron, Gaëlle, Callens, Céline, Rouleau, Etienne, Vincent-Salomon, Anne, Servant, Nicolas, Alt, Marie, Rouzier, Roman, Paoletti, Xavier, Delattre, Olivier, Bièche, Ivan
Publicado no J Natl Cancer Inst (2015)

Phase I Combination of Sorafenib and Erlotinib Therapy in Solid Tumors: Safety, Pharmacokinetic and Pharmacodynamic Evaluation from an Expansion Cohort

Por Quintela-Fandino, Miguel, Le Tourneau, Christophe, Duran, Ignacio, Chen, Eric X., Wang, Lisa, Tsao, Ming, Bandarchi-Chamkhaleh, Bizhan, Pham, Nhu-Ann, Do, Trevor, MacLean, Martha, Nayyar, Rakesh, Tusche, Michael W., Metser, Ur, Wright, John J., Mak, Tak W., Siu, Lillian L.
Publicado em 2010

Identification of new candidate therapeutic target genes in head and neck squamous cell carcinomas

Por Sablin, Marie-Paule, Dubot, Coraline, Klijanienko, Jerzy, Vacher, Sophie, Ouafi, Lamia, Chemlali, Walid, Caly, Martial, Sastre-Garau, Xavier, Lappartient, Emmanuelle, Mariani, Odette, Rodriguez, José, Jouffroy, Thomas, Girod, Angélique, Calugaru, Valentin, Hoffmann, Caroline, Lidereau, Rosette, Berger, Frédérique, Kamal, Maud, Bieche, Ivan, Le Tourneau, Christophe
Publicado no Oncotarget (2016)

Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis

Por Wassef, Michel, Rodilla, Veronica, Teissandier, Aurélie, Zeitouni, Bruno, Gruel, Nadege, Sadacca, Benjamin, Irondelle, Marie, Charruel, Margaux, Ducos, Bertrand, Michaud, Audrey, Caron, Matthieu, Marangoni, Elisabetta, Chavrier, Philippe, Le Tourneau, Christophe, Kamal, Maud, Pasmant, Eric, Vidaud, Michel, Servant, Nicolas, Reyal, Fabien, Meseure, Dider, Vincent-Salomon, Anne, Fre, Silvia, Margueron, Raphaël
Publicado no Genes Dev (2015)

Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial

Por Servant, Nicolas, Roméjon, Julien, Gestraud, Pierre, La Rosa, Philippe, Lucotte, Georges, Lair, Séverine, Bernard, Virginie, Zeitouni, Bruno, Coffin, Fanny, Jules-Clément, Gérôme, Yvon, Florent, Lermine, Alban, Poullet, Patrick, Liva, Stéphane, Pook, Stuart, Popova, Tatiana, Barette, Camille, Prud’homme, François, Dick, Jean-Gabriel, Kamal, Maud, Le Tourneau, Christophe, Barillot, Emmanuel, Hupé, Philippe
Publicado em 2014

First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors

Por Menke-van der Houven van Oordt, C. Willemien, Gomez-Roca, Carlos, van Herpen, Carla, Coveler, Andrew L., Mahalingam, Devalingam, Verheul, Henk M. W., van der Graaf, Winette T. A., Christen, Randolph, Rüttinger, Dominik, Weigand, Stefan, Cannarile, Michael A., Heil, Florian, Brewster, Michael, Walz, Antje-Christine, Nayak, Tapan K., Guarin, Ernesto, Meresse, Valerie, Le Tourneau, Christophe
Publicado no Oncotarget (2016)

Ligand–receptor dissociated expression explains high TSLP without prognostic impact in human primary head and neck squamous cell carcinoma

Por Guillot-Delost, Maude, Guilleré, Lia, Berger, Frédérique, Ventre, Aurore, Michea, Paula, Sirven, Philémon, Pattarini, Lucia, Scholer-Dahirel, Alix, Kebir, Fatima-Zahra, Huerre, Michel, Chouchane-Mlik, Olfa, Lappartient, Emmanuelle, Rodriguez, José, Jouffroy, Thomas, Klijanienko, Jerzy, Nicolas, André, Sastre-Garau, Xavier, Honorio, Sofia, Mosseri, Véronique, Le Peltier, Nelly, Sablin, Marie-Paule, Le Tourneau, Christophe, Tartour, Éric, Badoual, Cécile, Soumelis, Vassili
Publicado no Oncoimmunology (2016)

Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis

Por Lefebvre, Celine, Bachelot, Thomas, Filleron, Thomas, Pedrero, Marion, Campone, Mario, Soria, Jean-Charles, Massard, Christophe, Lévy, Christelle, Arnedos, Monica, Lacroix-Triki, Magali, Garrabey, Julie, Boursin, Yannick, Deloger, Marc, Fu, Yu, Commo, Frédéric, Scott, Véronique, Lacroix, Ludovic, Dieci, Maria Vittoria, Kamal, Maud, Diéras, Véronique, Gonçalves, Anthony, Ferrerro, Jean-Marc, Romieu, Gilles, Vanlemmens, Laurence, Mouret Reynier, Marie-Ange, Théry, Jean-Christophe, Le Du, Fanny, Guiu, Séverine, Dalenc, Florence, Clapisson, Gilles, Bonnefoi, Hervé, Jimenez, Marta, Le Tourneau, Christophe, André, Fabrice
Publicado no PLoS Med (2016)