Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis

Alterations of chromatin modifiers are frequent in cancer, but their functional consequences often remain unclear. Focusing on the Polycomb protein EZH2 that deposits the H3K27me3 (trimethylation of Lys27 of histone H3) mark, we showed that its high expression in solid tumors is a consequence, not a...

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Publicado en:Genes Dev
Autores principales: Wassef, Michel, Rodilla, Veronica, Teissandier, Aurélie, Zeitouni, Bruno, Gruel, Nadege, Sadacca, Benjamin, Irondelle, Marie, Charruel, Margaux, Ducos, Bertrand, Michaud, Audrey, Caron, Matthieu, Marangoni, Elisabetta, Chavrier, Philippe, Le Tourneau, Christophe, Kamal, Maud, Pasmant, Eric, Vidaud, Michel, Servant, Nicolas, Reyal, Fabien, Meseure, Dider, Vincent-Salomon, Anne, Fre, Silvia, Margueron, Raphaël
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2015
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699384/
https://ncbi.nlm.nih.gov/pubmed/26637281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.269522.115
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