Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis

Alterations of chromatin modifiers are frequent in cancer, but their functional consequences often remain unclear. Focusing on the Polycomb protein EZH2 that deposits the H3K27me3 (trimethylation of Lys27 of histone H3) mark, we showed that its high expression in solid tumors is a consequence, not a...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Wassef, Michel, Rodilla, Veronica, Teissandier, Aurélie, Zeitouni, Bruno, Gruel, Nadege, Sadacca, Benjamin, Irondelle, Marie, Charruel, Margaux, Ducos, Bertrand, Michaud, Audrey, Caron, Matthieu, Marangoni, Elisabetta, Chavrier, Philippe, Le Tourneau, Christophe, Kamal, Maud, Pasmant, Eric, Vidaud, Michel, Servant, Nicolas, Reyal, Fabien, Meseure, Dider, Vincent-Salomon, Anne, Fre, Silvia, Margueron, Raphaël
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699384/
https://ncbi.nlm.nih.gov/pubmed/26637281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.269522.115
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