Molecular architecture of photoreceptor phosphodiesterase elucidated by chemical cross-linking and integrative modeling

Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in visual excitation pathway in rod and cone photoreceptors. Its tight regulation is essential for the speed, sensitivity, recovery and adaptation of visual detection. Although major steps in the PDE6 activation/deactivation pathw...

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Udgivet i:J Mol Biol
Main Authors: Zeng-Elmore, Xiaohui, Gao, Xiong-Zhuo, Pellarin, Riccardo, Schneidman-Duhovny, Dina, Zhang, Xiu-Jun, Kozacka, Katie A., Tang, Yang, Sali, Andrej, Chalkley, Robert J., Cote, Rick H., Chu, Feixia
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253074/
https://ncbi.nlm.nih.gov/pubmed/25149264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.07.033
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