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Elucidating the mechanism of substrate recognition by the bacterial Hsp90 molecular chaperone

Hsp90 is a conformationally dynamic molecular chaperone known to promote the folding and activation of a broad array of protein substrates (“clients”). Hsp90 is believed to preferentially interact with partially folded substrates, and it has been hypothesized that the chaperone can significantly alt...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Street, Timothy O., Zeng, Xiaohui, Pellarin, Riccardo, Bonomi, Massimiliano, Sali, Andrej, Kelly, Mark J.S., Chu, Feixia, Agard, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322795/
https://ncbi.nlm.nih.gov/pubmed/24726919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.04.001
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