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Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone
Hsp90 is a ubiquitous molecular chaperone. Previous structural analysis demonstrated that Hsp90 can adopt a large number of structurally distinct conformations, however the functional role of this flexibility is not understood. Here we investigate the structural consequences of substrate binding wit...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3105473/ https://ncbi.nlm.nih.gov/pubmed/21474071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.029 |
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