Llwytho...

Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone

Hsp90 is a ubiquitous molecular chaperone. Previous structural analysis demonstrated that Hsp90 can adopt a large number of structurally distinct conformations, however the functional role of this flexibility is not understood. Here we investigate the structural consequences of substrate binding wit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Street, Timothy O., Lavery, Laura A., Agard, David A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105473/
https://ncbi.nlm.nih.gov/pubmed/21474071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.029
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!