De Novo Synthesis and Biological Evaluation of C6″-Substituted C4″-Amide Analogues of SL0101

[Image: see text] In an effort to improve upon the in vivo half-life of the known ribosomal s6 kinase (RSK) inhibitor SL0101, C4″-amide/C6″-alkyl substituted analogues of SL0101 were synthesized and evaluated in cell-based assays. The analogues were prepared using a de novo asymmetric synthetic appr...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Mrozowski, Roman M., Sandusky, Zachary M., Vemula, Rajender, Wu, Bulan, Zhang, Qi, Lannigan, Deborah A., O’Doherty, George A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251525/
https://ncbi.nlm.nih.gov/pubmed/25372628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol503012k
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