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The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4′-hydroxy†

Five cyclitol analogues of SL0101 with variable substitution at the C-4′ position (i.e., OH, Cl, F, H, OMe) were synthesized. The series of analogues were evaluated for their ability to inhibit p90 ribosomal S6 kinase (RSK) activity. The study demonstrated the importance of the B-ring C-4′ hydroxy g...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Li, Yu, Seber, Pedro, Wright, Eric B., Yasmin, Sharia, Lannigan, Deborah A., O’Doherty, George A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285658/
https://ncbi.nlm.nih.gov/pubmed/32048692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc00128g
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