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De Novo Synthesis and Biological Evaluation of C6″-Substituted C4″-Amide Analogues of SL0101
[Image: see text] In an effort to improve upon the in vivo half-life of the known ribosomal s6 kinase (RSK) inhibitor SL0101, C4″-amide/C6″-alkyl substituted analogues of SL0101 were synthesized and evaluated in cell-based assays. The analogues were prepared using a de novo asymmetric synthetic appr...
Gardado en:
| Publicado en: | Org Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American
Chemical Society
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4251525/ https://ncbi.nlm.nih.gov/pubmed/25372628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol503012k |
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