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Regioselective Synthesis of a C-4′′ Carbamate, C-6′′ n-Pr Substituted Cyclitol Analogue of SL0101
An asymmetric synthesis of two analogues of SL0101 (1) has been achieved. The effort is aimed at the discovery of inhibitors of the p90 ribosomal S6 kinase (RSK) with improved bioavailability. The route relies upon the use of the Taylor catalyst to regioselectively install C-3″ acetyl or carbamate f...
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| Publicado no: | Org Lett |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7292201/ https://ncbi.nlm.nih.gov/pubmed/32009414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c00042 |
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