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Analogues of the RSK inhibitor SL0101: Optimization of in vitro biological stability
The Ser/Thr protein kinase, RSK, is important in the etiology of tumor progression including invasion and motility. The natural product kaempferol-3-O-(3″,4″-di-O-acetyl-α-L-rhamnopyranoside), called SL0101, is a highly specific RSK inhibitor. Acylation of the rhamnose moiety is necessary for high a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3331937/ https://ncbi.nlm.nih.gov/pubmed/22464132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.03.033 |
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