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Coupled Protein Diffusion and Folding in the Cell

When a protein unfolds in the cell, its diffusion coefficient is affected by its increased hydrodynamic radius and by interactions of exposed hydrophobic residues with the cytoplasmic matrix, including chaperones. We characterize protein diffusion by photobleaching whole cells at a single point, and...

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Veröffentlicht in:PLoS One
Hauptverfasser: Guo, Minghao, Gelman, Hannah, Gruebele, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249841/
https://ncbi.nlm.nih.gov/pubmed/25436502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113040
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