HIV-1 Group O Integrase Displays Lower Enzymatic Efficiency and Higher Susceptibility to Raltegravir than HIV-1 Group M Subtype B Integrase

HIV-1 group O (HIV-O) is a rare HIV-1 variant characterized by a high number of polymorphisms, especially in the integrase coding region. As HIV-O integrase enzymes have not previously been studied, our aim was to assess the impact of HIV-O integrase polymorphisms on enzyme function and susceptibili...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Depatureaux, Agnès, Quashie, Peter K., Mesplède, Thibault, Han, Yingshan, Koubi, Hannah, Plantier, Jean-Christophe, Oliveira, Maureen, Moisi, Daniela, Brenner, Bluma, Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249541/
https://ncbi.nlm.nih.gov/pubmed/25224008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03819-14
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