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In Vitro Selection of Neisseria gonorrhoeae Mutants with Elevated MIC Values and Increased Resistance to Cephalosporins

Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with el...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Johnson, Steven R., Grad, Yonatan, Ganakammal, Satishkumar Ranganathan, Burroughs, Mark, Frace, Mike, Lipsitch, Marc, Weil, Ryan, Trees, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249396/
https://ncbi.nlm.nih.gov/pubmed/25199775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03082-14
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