Effect of Variants of Penicillin-Binding Protein 2 on Cephalosporin and Carbapenem Susceptibilities in Neisseria gonorrhoeae

To characterize the relationship between penicillin-binding protein 2 (PBP2/penA) and susceptibility to extended-spectrum cephalosporins (ESCs) and carbapenem antibiotics, we compared 17 PBP2 variants in Neisseria gonorrhoeae. Nonmosaic and mosaic variants of PBP2 caused decreased susceptibility to...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Bharat, Amrita, Demczuk, Walter, Martin, Irene, Mulvey, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505281/
https://ncbi.nlm.nih.gov/pubmed/25987627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05143-14
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