In Vitro Selection of Neisseria gonorrhoeae Mutants with Elevated MIC Values and Increased Resistance to Cephalosporins

Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with el...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Johnson, Steven R., Grad, Yonatan, Ganakammal, Satishkumar Ranganathan, Burroughs, Mark, Frace, Mike, Lipsitch, Marc, Weil, Ryan, Trees, David
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249396/
https://ncbi.nlm.nih.gov/pubmed/25199775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03082-14
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