In Vitro Selection of Neisseria gonorrhoeae Mutants with Elevated MIC Values and Increased Resistance to Cephalosporins

Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with el...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Johnson, Steven R., Grad, Yonatan, Ganakammal, Satishkumar Ranganathan, Burroughs, Mark, Frace, Mike, Lipsitch, Marc, Weil, Ryan, Trees, David
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249396/
https://ncbi.nlm.nih.gov/pubmed/25199775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03082-14
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