Blockade of Indoleamine 2,3-Dioxygenase Reduces Mortality from Peritonitis and Sepsis in Mice by Regulating Functions of CD11b(+) Peritoneal Cells

Indoleamine 2,3-dioxygenase-1 (Ido), which catalyzes the first and limiting step of tryptophan catabolism, has been implicated in immune tolerance. However, the roles of Ido in systemic bacterial infection are complicated and remain controversial. To explore this issue, we examined the roles of Ido...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Infect Immun
Main Authors: Hoshi, Masato, Osawa, Yosuke, Ito, Hiroyasu, Ohtaki, Hirofumi, Ando, Tatsuya, Takamatsu, Manabu, Hara, Akira, Saito, Kuniaki, Seishima, Mitsuru
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Host Response and Inflammation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249307/
https://ncbi.nlm.nih.gov/pubmed/25114116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02113-14
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