Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice

Indoleamine 2,3-dioxygenase (IDO), an enzyme that degrades the essential amino acid l-tryptophan along the kynurenine pathway, exerts immunomodulatory effects in a number of diseases. IDO expression is increased in tumor tissue and in draining lymph nodes; this increase is thought to play a role in...

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Publicado en:Cancer Sci
Autores principales: Takamatsu, Manabu, Hirata, Akihiro, Ohtaki, Hirofumi, Hoshi, Masato, Ando, Tatsuya, Ito, Hiroyasu, Hatano, Yuichiro, Tomita, Hiroyuki, Kuno, Toshiya, Saito, Kuniaki, Seishima, Mitsuru, Hara, Akira
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Ltd 2015
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556390/
https://ncbi.nlm.nih.gov/pubmed/26033215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12705
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