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Blockade of Indoleamine 2,3-Dioxygenase Reduces Mortality from Peritonitis and Sepsis in Mice by Regulating Functions of CD11b(+) Peritoneal Cells

Indoleamine 2,3-dioxygenase-1 (Ido), which catalyzes the first and limiting step of tryptophan catabolism, has been implicated in immune tolerance. However, the roles of Ido in systemic bacterial infection are complicated and remain controversial. To explore this issue, we examined the roles of Ido...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Hoshi, Masato, Osawa, Yosuke, Ito, Hiroyasu, Ohtaki, Hirofumi, Ando, Tatsuya, Takamatsu, Manabu, Hara, Akira, Saito, Kuniaki, Seishima, Mitsuru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249307/
https://ncbi.nlm.nih.gov/pubmed/25114116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02113-14
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