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Contrasting behavior of the p18(INK4c) and p16(INK4a) tumor suppressors in both replicative and oncogene-induced senescence
The CDK inhibitors, p18(INK4c) and p16(INK4a), both have the credentials of tumor suppressors in human cancers and mouse models. For p16(INK4a), the underlying rationale is its role in senescence but the selective force for inactivation of p18(INK4c) in incipient cancer cells is less clear. Here we...
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| Publicado no: | Cancer Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4248231/ https://ncbi.nlm.nih.gov/pubmed/22080569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2552 |
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