Systemic oxygenation weakens the hypoxia and Hypoxia Inducible Factor 1α-dependent and extracellular adenosine-mediated tumor protection

Intratumoral hypoxia and Hypoxia Inducible Factor-1α (HIF-1α)-dependent CD39/CD73 ecto-enzymes may govern the accumulation of tumor-protecting extracellular adenosine and signaling through the A2A adenosine receptors (A2AR) in tumor microenvironments (TME). Here, we explored the conceptually novel m...

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Foilsithe in:J Mol Med (Berl)
Main Authors: Hatfield, Stephen M., Kjaergaard, Jorgen, Lukashev, Dmitriy, Belikoff, Bryan, Schreiber, Taylor H., Sethumadhavan, Shalini, Abbott, Robert, Philbrook, Phaethon, Thayer, Molly, Shujia, Dai, Rodig, Scott, Kutok, Jeffrey L., Ren, Jin, Ohta, Akio, Podack, Eckhard R., Karger, Barry, Jackson, Edwin K., Sitkovsky, Michail
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247798/
https://ncbi.nlm.nih.gov/pubmed/25120128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-014-1189-3
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