Systemic oxygenation weakens the hypoxia and Hypoxia Inducible Factor 1α-dependent and extracellular adenosine-mediated tumor protection

Intratumoral hypoxia and Hypoxia Inducible Factor-1α (HIF-1α)-dependent CD39/CD73 ecto-enzymes may govern the accumulation of tumor-protecting extracellular adenosine and signaling through the A2A adenosine receptors (A2AR) in tumor microenvironments (TME). Here, we explored the conceptually novel m...

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Vydáno v:J Mol Med (Berl)
Hlavní autoři: Hatfield, Stephen M., Kjaergaard, Jorgen, Lukashev, Dmitriy, Belikoff, Bryan, Schreiber, Taylor H., Sethumadhavan, Shalini, Abbott, Robert, Philbrook, Phaethon, Thayer, Molly, Shujia, Dai, Rodig, Scott, Kutok, Jeffrey L., Ren, Jin, Ohta, Akio, Podack, Eckhard R., Karger, Barry, Jackson, Edwin K., Sitkovsky, Michail
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247798/
https://ncbi.nlm.nih.gov/pubmed/25120128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-014-1189-3
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