BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs

Colorectal tumorigenesis is driven by genetic alterations in the adenomatous polyposis coli (APC) tumor suppressor pathway and effectively inhibited by nonsteroidal antiinflammatory drugs (NSAIDs). However, how NSAIDs prevent colorectal tumorigenesis has remained obscure. We found that the extrinsic...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Leibowitz, Brian, Qiu, Wei, Buchanan, Monica E., Zou, Fangdong, Vernon, Philip, Moyer, Mary P., Yin, Xiao-Ming, Schoen, Robert E., Yu, Jian, Zhang, Lin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246283/
https://ncbi.nlm.nih.gov/pubmed/25368155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415178111
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