BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs

Colorectal tumorigenesis is driven by genetic alterations in the adenomatous polyposis coli (APC) tumor suppressor pathway and effectively inhibited by nonsteroidal antiinflammatory drugs (NSAIDs). However, how NSAIDs prevent colorectal tumorigenesis has remained obscure. We found that the extrinsic...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Leibowitz, Brian, Qiu, Wei, Buchanan, Monica E., Zou, Fangdong, Vernon, Philip, Moyer, Mary P., Yin, Xiao-Ming, Schoen, Robert E., Yu, Jian, Zhang, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246283/
https://ncbi.nlm.nih.gov/pubmed/25368155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415178111
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