Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice

Osteopontin (OPN) is a secreted phosphoglycoprotein, and is a transcriptional target of aberrant Wnt signaling. OPN is upregulated in human colon cancers, and is suggested to enhance cancer progression. In this study, the effect of deficiency of OPN on intestinal tumor development in Apc-deficient M...

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Main Authors: Rikako Ishigamori, Masami Komiya, Shinji Takasu, Michihiro Mutoh, Toshio Imai, Mami Takahashi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2017-05-01
Colecção:International Journal of Molecular Sciences
Assuntos:
osteopontin
colorectal tumor
macrophage
Acesso em linha:http://www.mdpi.com/1422-0067/18/5/1058
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