Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc(Min/+) mice

Excessive prostaglandin production by cyclooxygenase-2 in stromal and epithelial cells is a causative factor of colorectal carcinogenesis. Thus, compounds which inhibit cyclooxygenase-2 transcriptional activity in colon epithelial cells could be candidates for anti-carcinogenic agents. A cyclooxygen...

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Autori principali: Shimizu, Satomi, Fujii, Gen, Takahashi, Mami, Nakanishi, Ruri, Komiya, Masami, Shimura, Misato, Noma, Nobuharu, Onuma, Wakana, Terasaki, Masaru, Yano, Tomohiro, Mutoh, Michihiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: the Society for Free Radical Research Japan 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947973/
https://ncbi.nlm.nih.gov/pubmed/24688218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.13-91
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