BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs

Colorectal tumorigenesis is driven by genetic alterations in the adenomatous polyposis coli (APC) tumor suppressor pathway and effectively inhibited by nonsteroidal antiinflammatory drugs (NSAIDs). However, how NSAIDs prevent colorectal tumorigenesis has remained obscure. We found that the extrinsic...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Leibowitz, Brian, Qiu, Wei, Buchanan, Monica E., Zou, Fangdong, Vernon, Philip, Moyer, Mary P., Yin, Xiao-Ming, Schoen, Robert E., Yu, Jian, Zhang, Lin
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246283/
https://ncbi.nlm.nih.gov/pubmed/25368155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415178111
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares