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GFP-Based Fluorescence Assay for CAG Repeat Instability in Cultured Human Cells

Trinucleotide repeats can be highly unstable, mutating far more frequently than point mutations. Repeats typically mutate by addition or loss of units of the repeat. CAG repeat expansions in humans trigger neurological diseases that include myotonic dystrophy, Huntington disease, and several spinoce...

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Publicado en:PLoS One
Main Authors: Santillan, Beatriz A., Moye, Christopher, Mittelman, David, Wilson, John H.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244167/
https://ncbi.nlm.nih.gov/pubmed/25423602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113952
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