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Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells
Expanded triplet repeats have been identified as the genetic basis for a growing number of neurological and skeletal disorders. To examine the contribution of double-strand break repair to CAG·CTG repeat instability in mammalian systems, we developed zinc finger nucleases (ZFNs) that recognize and c...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701052/ https://ncbi.nlm.nih.gov/pubmed/19482946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902420106 |
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