Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells

Expanded triplet repeats have been identified as the genetic basis for a growing number of neurological and skeletal disorders. To examine the contribution of double-strand break repair to CAG·CTG repeat instability in mammalian systems, we developed zinc finger nucleases (ZFNs) that recognize and c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mittelman, David, Moye, Christopher, Morton, Jason, Sykoudis, Kristen, Lin, Yunfu, Carroll, Dana, Wilson, John H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2009
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701052/
https://ncbi.nlm.nih.gov/pubmed/19482946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902420106
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