Somatic mutation of CDKN1B in small intestine neuroendocrine tumors

The diagnosed incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, and the underlying genomic mechanisms have not been defined for these tumors. Using exome/genome sequence analysis of SI-NETs, we identified recurrent somatic mutations and deletions in CDKN1B, the cyclin-depen...

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Опубликовано в: :Nat Genet
Главные авторы: Francis, Joshua M., Kiezun, Adam, Ramos, Alex H., Serra, Stefano, Pedamallu, Chandra Sekhar, Qian, Zhi Rong, Banck, Michaela S., Kanwar, Rahul, Kulkarni, Amit A., Karpathakis, Anna, Manzo, Veronica, Contractor, Tanupriya, Philips, Juliet, Nickerson, Elizabeth, Pho, Nam, Hooshmand, Susanne M., Brais, Lauren K., Lawrence, Michael, Pugh, Trevor, McKenna, Aaron, Sivachenko, Andrey, Cibulskis, Kristian, Carter, Scott L., Ojesina, Akinyemi I., Freeman, Samuel, Jones, Robert T., Voet, Douglas, Saksena, Gordon, Auclair, Daniel, Onofrio, Robert, Shefler, Erica, Sougnez, Carrie, Grimsby, Jonna, Green, Lisa, Lennon, Niall, Meyer, Tim, Caplin, Martyn, Chung, Daniel C., Beutler, Andreas S., Ogino, Shuji, Thirlwell, Christina, Shivdasani, Ramesh, Asa, Sylvia L., Harris, Chris R., Getz, Gad, Kulke, Matthew, Meyerson, Matthew
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239432/
https://ncbi.nlm.nih.gov/pubmed/24185511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2821
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