Somatic mutation of CDKN1B in small intestine neuroendocrine tumors

The diagnosed incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, and the underlying genomic mechanisms have not been defined for these tumors. Using exome/genome sequence analysis of SI-NETs, we identified recurrent somatic mutations and deletions in CDKN1B, the cyclin-depen...

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Publicado en:Nat Genet
Main Authors: Francis, Joshua M., Kiezun, Adam, Ramos, Alex H., Serra, Stefano, Pedamallu, Chandra Sekhar, Qian, Zhi Rong, Banck, Michaela S., Kanwar, Rahul, Kulkarni, Amit A., Karpathakis, Anna, Manzo, Veronica, Contractor, Tanupriya, Philips, Juliet, Nickerson, Elizabeth, Pho, Nam, Hooshmand, Susanne M., Brais, Lauren K., Lawrence, Michael, Pugh, Trevor, McKenna, Aaron, Sivachenko, Andrey, Cibulskis, Kristian, Carter, Scott L., Ojesina, Akinyemi I., Freeman, Samuel, Jones, Robert T., Voet, Douglas, Saksena, Gordon, Auclair, Daniel, Onofrio, Robert, Shefler, Erica, Sougnez, Carrie, Grimsby, Jonna, Green, Lisa, Lennon, Niall, Meyer, Tim, Caplin, Martyn, Chung, Daniel C., Beutler, Andreas S., Ogino, Shuji, Thirlwell, Christina, Shivdasani, Ramesh, Asa, Sylvia L., Harris, Chris R., Getz, Gad, Kulke, Matthew, Meyerson, Matthew
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239432/
https://ncbi.nlm.nih.gov/pubmed/24185511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2821
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