Blocking Ligand Occupancy of the αVβ3 Integrin Inhibits the Development of Nephropathy in Diabetic Pigs

Hyperglycemia stimulates secretion of αVβ3 ligands from vascular cells, including endothelial cells, resulting in activation of the αVβ3 integrin. This study determined whether blocking ligand occupancy of αVβ3 would inhibit the development of diabetic nephropathy. Ten diabetic pigs received an F(ab...

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Bibliografiske detaljer
Udgivet i:Endocrinology
Main Authors: Maile, Laura A., Busby, Walker H., Gollahon, Katherine A., Flowers, William, Garbacik, Nikol, Garbacik, Stefani, Stewart, Kara, Nichols, Timothy, Bellinger, Dwight, Patel, Amit, Dunbar, Paul, Medlin, Matt, Clemmons, David
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2014
Fag:
Diabetes-Insulin-Glucagon-Gastrointestinal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239428/
https://ncbi.nlm.nih.gov/pubmed/25171599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1318
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