Blocking Ligand Occupancy of the αVβ3 Integrin Inhibits the Development of Nephropathy in Diabetic Pigs

Hyperglycemia stimulates secretion of αVβ3 ligands from vascular cells, including endothelial cells, resulting in activation of the αVβ3 integrin. This study determined whether blocking ligand occupancy of αVβ3 would inhibit the development of diabetic nephropathy. Ten diabetic pigs received an F(ab...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Endocrinology
Κύριοι συγγραφείς: Maile, Laura A., Busby, Walker H., Gollahon, Katherine A., Flowers, William, Garbacik, Nikol, Garbacik, Stefani, Stewart, Kara, Nichols, Timothy, Bellinger, Dwight, Patel, Amit, Dunbar, Paul, Medlin, Matt, Clemmons, David
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Endocrine Society 2014
Θέματα:
Diabetes-Insulin-Glucagon-Gastrointestinal
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239428/
https://ncbi.nlm.nih.gov/pubmed/25171599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1318
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