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Role of the Integrin αVβ3 in Mediating Increased Smooth Muscle Cell Responsiveness to IGF-I in Response to Hyperglycemic Stress
Under usual conditions, the role of IGF-I in vascular cell types is to maintain cellular protein synthesis and cell size, and even excess IGF-I does not stimulate proliferation. In pathophysiologic states, such as hyperglycemia, smooth muscle cells (SMC) de-differentiate and change their responsiven...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2366026/ https://ncbi.nlm.nih.gov/pubmed/17412627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ghir.2007.01.004 |
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