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Optimizing the specificity of nucleic acid hybridization

The specific hybridization of complementary sequences is an essential property of nucleic acids, enabling diverse biological and biotechnological reactions and functions. However, the specificity of nucleic acid hybridization is compromised for long strands, except near the melting temperature. Here...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Chem
Main Authors: Zhang, David Yu, Chen, Sherry Xi, Yin, Peng
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238961/
https://ncbi.nlm.nih.gov/pubmed/22354435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1246
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