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Modular probes for enriching and detecting complex nucleic acid sequences

Complex DNA sequences are difficult to detect and profile, but are important contributors to human health and disease. Existing hybridization probes lack the capability to selectively bind and enrich hypervariable, long or repetitive sequences. Here, we present a generalized strategy for constructin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nat Chem
Hauptverfasser: Wang, Juexiao Sherry, Yan, Yan Helen, Zhang, David Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788029/
https://ncbi.nlm.nih.gov/pubmed/29168489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2820
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