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Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA

DNA glycosylases remove damaged or enzymatically modified nucleobases from DNA, thereby initiating the base excision repair (BER) pathway, which is found in all forms of life. These ubiquitous enzymes promote genomic integrity by initiating repair of mutagenic and/or cytotoxic lesions that arise con...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Org Biomol Chem
Main Authors: Drohat, Alexander C., Maiti, Atanu
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238931/
https://ncbi.nlm.nih.gov/pubmed/25181003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4ob01063a
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