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Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA

5-methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and genome stability, and aberrant DNA methylation contributes to aging and cancer. Active DNA demethylation involves stepwise oxidation of mC to 5-hydroxymethylcytosine, 5-formylcytosine (fC), and potentially 5-car...

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Autors principals: Maiti, Atanu, Michelson, Anna Zhachkina, Armwood, Cherece J, Lee, Jeehiun K, Drohat, Alexander C
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930231/
https://ncbi.nlm.nih.gov/pubmed/24063363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja406444x
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