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Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA
5-methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and genome stability, and aberrant DNA methylation contributes to aging and cancer. Active DNA demethylation involves stepwise oxidation of mC to 5-hydroxymethylcytosine, 5-formylcytosine (fC), and potentially 5-car...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930231/ https://ncbi.nlm.nih.gov/pubmed/24063363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja406444x |
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