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Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA

5-methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and genome stability, and aberrant DNA methylation contributes to aging and cancer. Active DNA demethylation involves stepwise oxidation of mC to 5-hydroxymethylcytosine, 5-formylcytosine (fC), and potentially 5-car...

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Библиографические подробности
Главные авторы: Maiti, Atanu, Michelson, Anna Zhachkina, Armwood, Cherece J, Lee, Jeehiun K, Drohat, Alexander C
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930231/
https://ncbi.nlm.nih.gov/pubmed/24063363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja406444x
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