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Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA

5-methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and genome stability, and aberrant DNA methylation contributes to aging and cancer. Active DNA demethylation involves stepwise oxidation of mC to 5-hydroxymethylcytosine, 5-formylcytosine (fC), and potentially 5-car...

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Bibliografiske detaljer
Main Authors: Maiti, Atanu, Michelson, Anna Zhachkina, Armwood, Cherece J, Lee, Jeehiun K, Drohat, Alexander C
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930231/
https://ncbi.nlm.nih.gov/pubmed/24063363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja406444x
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