TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is associated with cellular ageing. Telomere protection involves the insertion of the 3′ overhang facilitated by telomere repeat-binding factor 2 (TRF2) into telomeric DNA, forming t-loops. We present evidence suggesting...

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發表在:Nat Commun
Main Authors: Wood, Ashley M., Danielsen, Jannie M. Rendtlew, Lucas, Catherine A., Rice, Ellen L., Scalzo, David, Shimi, Takeshi, Goldman, Robert D., Smith, Erica D., Le Beau, Michelle M., Kosak, Steven T.
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235626/
https://ncbi.nlm.nih.gov/pubmed/25399868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6467
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