TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is associated with cellular ageing. Telomere protection involves the insertion of the 3′ overhang facilitated by telomere repeat-binding factor 2 (TRF2) into telomeric DNA, forming t-loops. We present evidence suggesting...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Wood, Ashley M., Danielsen, Jannie M. Rendtlew, Lucas, Catherine A., Rice, Ellen L., Scalzo, David, Shimi, Takeshi, Goldman, Robert D., Smith, Erica D., Le Beau, Michelle M., Kosak, Steven T.
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235626/
https://ncbi.nlm.nih.gov/pubmed/25399868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6467
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items